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THE EFFECTS OF INTRACEREBROVENTRICULAR CYCLOHEXIMIDE ON PROTEIN SYNTHESIS AND FEVER IN RABBITS
Author(s) -
CRANSTON W.I.,
GOURINE V.N.,
TOWNSEND Y.
Publication year - 1981
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1981.tb16763.x
Subject(s) - cycloheximide , thermoregulation , protein biosynthesis , leucine , endocrinology , medicine , chemistry , biology , biochemistry , amino acid
Cycloheximide(40μg)intracerebroventricularly(i.c.v.) had no effect on thermoregulation against cold, but reduced fever due to an i.e.v. injection of leucocyte pyrogen (LP) by 25%. and reduced incorporation of radioactive leucine into hypothalamic protein by 94%.