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LEUKOTRIENE B 4 : A MEDIATOR OF VASCULAR PERMEABILITY
Author(s) -
BRAY M.A.,
CUNNINGHAM F.M.,
FORDHUTCHINSON A.W.,
SMITH M.J.H.
Publication year - 1981
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1981.tb11000.x
Subject(s) - bradykinin , leukotriene b4 , intradermal injection , guinea pig , vascular permeability , leukotriene , prostaglandin e2 , vasodilation , pharmacology , chemistry , endocrinology , immunology , medicine , biology , biochemistry , inflammation , receptor , asthma
1 Intradermal injection of leukotriene B 4 (LTB 4 ) or prostaglandin E 2 (PGE 2 ), 1 to 100 ng per skin site produced little or no change in plasma exudation in the rabbit, guinea‐pig and rat. 2 Intradermal injection of LTB 4 together with PGE 2 produced a significant increase in plasma exudation in the rabbit, guinea‐pig and rat. 3 Intradermal injection of LTB 4 or PGE 2 together with bradykinin (500 ng) resulted in a significant potentiation of the plasma exudation produced by bradykinin alone in the rabbit and guinea‐pig. 4 LTB 4 (1 to 10 ng) had no effect on blood flow in the rabbit skin, in contrast to PGE 2 which was a potent vasodilator in this species. 5 It is concluded that LTB 4 is a mediator of vascular permeability and that this effect can only be observed in the presence of a vasodilator such as PGE 2 .