Premium
LEUKOTRIENES C 4 AND D 4 INDUCE PROSTAGLANDIN AND THROMBOXANE RELEASE FROM RAT PERITONEAL MACROPHAGES
Author(s) -
FEUERSTEIN NILI,
FOEGH MARIE,
RAMWELL PETER W.
Publication year - 1981
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1981.tb10988.x
Subject(s) - prostaglandin , prostaglandin f , chemistry , thromboxane , thromboxane b2 , prostaglandin d2 , pharmacology , thromboxane a synthase , leukotriene , endocrinology , medicine , biochemistry , platelet , asthma
The present study examined the effect of leukotrienes C 4 and D 4 , the products of the 5′ lipoxygenase pathway on prostaglandins and thromboxane release from rat peritoneal macrophages. Incubation of rat peritoneal macrophages with leukotrienes C 4 and D 4 enhanced the release of prostaglandin E 2 (PGE 2 ), 6‐keto PGF 1α and thromboxane B 2 (TxB 2 ) in a dose‐dependent manner. The increase of PGE 2 was more pronounced than that of 6‐keto‐PGF 1α and TxB 2 . Lipopolysaccharide, a known stimulator of these cells elicited a similar pattern of increase of the arachidonate metabolites assayed. These results suggest that leukotrienes C 4 and D 4 are potential activators of macrophages. Since leukotrienes C 4 and D 4 are produced by these cells, it is suggested that endogenous leukotrienes may be involved in activation of macrophages.