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STIMULATION OF RAT CEREBELLAR GUANOSINE 3‘,5’‐CYCLIC MONOPHOSPHATE (CYCLIC GMP) LEVELS: EFFECTS OF AMINO ACID ANTAGONISTS
Author(s) -
FOSTER GEORGE A.,
ROBERTS PETER J.
Publication year - 1981
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1981.tb10484.x
Subject(s) - guanosine , cyclic guanosine monophosphate , glutamate receptor , antagonist , chemistry , excitatory postsynaptic potential , stimulation , postsynaptic potential , biochemistry , biophysics , receptor , endocrinology , biology , organic chemistry , nitric oxide
1 The ability of glutamate, aspartate and related neuroexcitants to produce large calcium‐dependent increases in the levels of guanosine 3′,5′‐cyclic monophosphate (cyclic GMP) in immature rat cerebellar slices has been demonstrated. 2 These effects were inhibited by selective antagonist compounds, indicating the presence of at least two types of excitatory amino acid receptor mediating the cyclic GMP response. 3 Protoveratrine also produced large increases in cyclic GMP, and this action was antagonized by L‐glutamate diethylester suggesting that released endogenous glutamate, subsequently interacting with its postsynaptic receptors, is the predominant mechanism. 4 The kinetic characteristics of several of the inhibitor compounds were investigated.