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In vivo AND in vitro EFFECTS OF ENDOTOXIN ON PROSTAGLANDIN RELEASE FROM RAT LUNG
Author(s) -
FEUERSTEIN NILI,
RAMWELL PETER W.
Publication year - 1981
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1981.tb10450.x
Subject(s) - in vivo , in vitro , pharmacology , prostaglandin , chemistry , lung , medicine , biology , biochemistry , microbiology and biotechnology
1 The release of prostaglandins (PGE 2 , PGF 2α , PGI 2 ) and thromboxane A 2 (T×A 2 ) from rat lung exposed to E. coli endotoxin, in vivo ox in vitro has been studied. 2 Lung strips of endotoxin‐treated rats demonstrated a preferential increase of T×A 2 and PGF 2α and a decrease in the ratio PGI 2 /T×A 2 . 3 These data suggest that changes in the proportions of arachidonic acid metabolites might play a role in the pulmonary pathophysiology during endotoxin shock. 4 Incubation of lung strips with endotoxin in vitro failed to stimulate prostaglandin release; paradoxically, it suppressed both the spontaneous and the ionophore‐induced prostaglandin release. 5 These findings suggest that the increase in prostaglandin release by the lung following endotoxin administration in vivo is probably mediated by factor(s) generated in endotoxaemia and is not due to a direct action of endotoxin on the lung tissue.