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THEOPHYLLINE INHIBITION OF RENAL AND CEREBRAL NUCLEOSIDE FORMATION
Author(s) -
JENSEN MOGENS H.
Publication year - 1981
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1981.tb10444.x
Subject(s) - theophylline , adenosine , purine , nucleoside , purine metabolism , chemistry , kidney , central nervous system , endogeny , adenosine monophosphate , pharmacology , medicine , endocrinology , enzyme , biology , biochemistry
1 Theophylline inhibits the enzymatic formation of purine nucleosides, among these adenosine (dephosphorylated adenosine 5′‐monophosphate), in kidney and brain of the rat. 2 Some pharmacological effects of theophylline on regional blood flow and electrophysiological activity of the nervous system may be caused by inhibition of the endogenous formation of adenosine.