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A RE‐EVALUATION OF ACETYLCHOLINE RECEPTORS ON FELINE RENSHAW CELLS
Author(s) -
KING K.T.,
RYALL R.W.
Publication year - 1981
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1981.tb10442.x
Subject(s) - muscarine , renshaw cell , muscarinic acetylcholine receptor , acetylcholine , atropine , chemistry , nicotine , nicotinic agonist , receptor , pharmacology , acetylcholine receptor , muscarinic acetylcholine receptor m2 , cats , medicine , inhibitory postsynaptic potential , biology , biochemistry
1 The effects of atropine, methylatropine and lachesine administered by ionophoresis were examined on responses of Renshaw cells to acetylcholine, acetyl‐β‐methylcholine, nicotine and DL‐muscarine in cats anaesthetized with pentobarbitone or chloralose. 2 The antagonists were as effective in antagonizing excitation by nicotine as they were in antagonizing excitation by acetylcholine and were only slightly more effective in antagonizing excitation by acetyl‐β‐methylcholine. 3 These results are discussed in relation to the characterization of acetylcholine receptors on Renshaw cells. 4 It is concluded that there are two distinct populations of receptors but that the nicotinic receptors are non‐selective in their activation by agonists and antagonists, whereas the muscarinic receptors display greater selectivity.