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INHIBITORY EFFECTS OF PROPRANOLOL ON THE CALCIUM CURRENT OF Helix NEURONES
Author(s) -
AKAIKE N.,
NISHI K.,
OYAMA Y.
Publication year - 1981
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1981.tb10439.x
Subject(s) - propranolol , inhibitory postsynaptic potential , pipette , calcium , chemistry , biophysics , potassium , voltage clamp , patch clamp , membrane potential , potassium channel , endocrinology , pharmacology , medicine , receptor , biology , biochemistry , organic chemistry
1 Calcium current (I Ca ) and potassium current (I K ) in isolated nerve cell bodies of Helix aspersa were independently separated after suppression of Na + and K + currents, and Na + and Ca 2+ currents, respectively. The suction pipette method was used. Under voltage clamp conditions, the effects of propranolol on both the I Ca and I K were examined. 2 Propranolol inhibits the I Ca at relatively low concentrations (10 −6 ‐10 −5 m). The inhibitory action was dose‐dependent. 3 The I K was moderately suppressed by the drug at high concentrations (10 −5 ‐5 × 10 −4 m). 4 Results provide evidence for a new aspect of the pharmacological action of propranolol on the excitable cell membrane.