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ANTIFIBRILLATORY EFFICACY OF ENCAINIDE, LORCAINIDE AND ORG 6001 COMPARED WITH LIGNOCAINE IN ISOLATED HEARTS OF RABBITS AND GUINEA‐PIGS
Author(s) -
ALMOTREFI A. A.,
BAKER J. B.E.
Publication year - 1981
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1981.tb10431.x
Subject(s) - ventricular fibrillation , ouabain , lidocaine , perfusion , stimulation , guinea pig , medicine , cardiology , anesthesia , anti arrhythmia agents , pharmacology , chemistry , atrial fibrillation , sodium , organic chemistry
1 In Langendorff‐perfused rabbit hearts, electrical stimulation threshold and ventricular fibrillation threshold (VFT) were measured by applying rectangular impulses of 3 ms duration and increasing current at frequencies of 4 and 20 Hz respectively. 2 Perfusion with lignocaine or one of three new antiarrhythmic drugs, encainide, lorcainide and ORG 6001, produced significant, dose‐dependent increases in both thresholds. 3 On a dosage basis, encainide was seven times, lorcainide fourteen times and ORG 6001 twice as potent as lignocaine in raising VFT. 4 In Langendorff‐perfused guinea‐pig hearts, only lorcainide provided complete protection against ouabain‐induced ventricular fibrillation, while 6 of 6,3 of 6 and 2 of 6 hearts fibrillated in the presence of encainide, lignocaine and ORG 6001 respectively, but with infusion durations significantly higher than control. 5 These results indicate the potential antifibrillatory activity of these new antiarrhythmic agents.