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PARALLEL MATURATION OF THE PANCREATIC SECRETORY RESPONSE TO CHOLINERGIC STIMULATION AND THE MUSCARINIC RECEPTOR POPULATION
Author(s) -
DUMONT Y.,
LAROSE L.,
MORISSET J.,
POIRIER G.G.
Publication year - 1981
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1981.tb10428.x
Subject(s) - muscarinic acetylcholine receptor , endocrinology , medicine , agonist , population , quinuclidinyl benzilate , stimulation , cholinergic , pancreas , receptor , biology , acetylcholine , chemistry , environmental health
1 The appearance of pancreatic muscarinic receptors during development has been measured by use of the specific ligand [ 3 H]‐quinuclidinyl benzilate ([ 3 H]‐QNB). 2 QNB binding sites are present in foetal pancreas; their maximal concentration is attained at the age of 30 days and a significant decrease is observed in one year old animals. 3 Affinity of [ 3 H]‐QNB for the muscarinic receptor does not change with age. 4 An evaluation of the pancreatic secretory response to a cholinoceptor agonist as a function of age indicates that the development of this response parallels that of the receptor population. 5 It is suggested that, at all ages from 3 days after birth onwards, the maximal secretory response of the exocrine pancreas to a cholinoceptor agonist mobilizes the same proportion of the total population of QNB binding sites.