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A COMPARISON OF THE EFFECTS OF NIFEDIPINE AND VERAPAMIL ON RAT VAS DEFERENS
Author(s) -
FRENCH A.M.,
SCOTT N.C.
Publication year - 1981
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1981.tb10424.x
Subject(s) - vas deferens , nifedipine , verapamil , medicine , pharmacology , endocrinology , calcium
Nifedipine preferentially blocks contractions of the prostatic end of the rat vas deferens to single pulse field stimulation, leaving the epididymal end largely unaffected. This action is not due entirely to antagonism of calcium influx. Verapamil unexpectedly potentiated the responses of the prostatic portion, and antagonized those of the epididymal end. The use of nifedipine may, therefore, allow investigations of adrenergic mechanisms on this tissue to be studied without the complications of non‐adrenergic transmission.