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PROSTAGLANDINS RELEASE PLASMA ‘RECIPROCAL COUPLING FACTOR’ IN ANAESTHETIZED RATS
Author(s) -
HOULT J.R.S.,
MOORE P.K.
Publication year - 1981
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1981.tb09994.x
Subject(s) - prostaglandin , acetylcholine , chemistry , histamine , prostaglandin e , metabolite , endocrinology , medicine , in vivo , prostaglandin antagonist , pharmacology , biochemistry , biology , microbiology and biotechnology
1 Prostaglandins E 1 , E 2 , I 2 and endoperoxide analogue U46619 injected intra‐arterially (i.a.) into anaesthetized rats at 2 μg/kg caused a substantial increase within 60 min of the plasma activity of prostaglandin ‘reciprocal coupling factor’ (RCF). RCF is the provisional name for the component(s) of plasma which inhibit microsomal prostaglandin synthesis and enhance cytosolic prostaglandin breakdown 2 RCF is not released by inactive metabolite 13, 14‐dihydro‐15‐keto prostaglandin E 2 (10 μg/kg, i.a.) or acetylcholine or histamine (2 μg/kg, i.a.) 3 We suggest that release by prostaglandins of RCF could provide the basis in vivo for a negative feedback mechanism controlling the activity of the prostaglandin system.