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SELECTIVE INHIBITION OF THROMBOXANE BIOSYNTHESIS IN HUMAN BLOOD MONONUCLEAR CELLS AND THE EFFECTS ON MITOGEN‐STIMULATED LYMPHOCYTE PROLIFERATION
Author(s) -
GORDON D.,
NOURI A.M.E.,
THOMAS R.U.
Publication year - 1981
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1981.tb09992.x
Subject(s) - thromboxane , peripheral blood mononuclear cell , thromboxane b2 , prostaglandin e , dna synthesis , lymphocyte , prostaglandin , chemistry , thromboxane a2 , endocrinology , medicine , pharmacology , biochemistry , biology , platelet , receptor , in vitro
1 The effects of six imidazole compounds were examined on thromboxane B 2 (TxB 2 ) and prostaglandin E 2 (PGE 2 ) production and mitogen‐stimulated lymphocyte transformation in human blood mononuclear cells 2 UK 37248 (4‐(2‐[IH‐imidazol‐l‐yl]ethoxy)benzoic acid), imidazole and 1‐methylimidazole selectively inhibited TxB 2 synthesis in a dose‐related manner, with corresponding increases in PGE 2 production 3 Clotrimazole, benzimidazole and 2‐methylimidazole preferentially inhibited TxB synthesis but had little effect on PGE 2 production 4 Clotrimazole and benzimidazole inhibited proliferative responses of the lymphocytes, but UK 37248 and 1‐methylimidazole did not affect transformation at concentrations which inhibited TxB 2 synthesis to a similar level (over 90%) 5 The results do not support involvement of endogenous TxB 2 in the process of lymphocyte mitogenesis or in the mechanism of the suppressive effects of some TxB 2 synthetase inhibitors.