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THE EFFECTS OF PROSTAGLANDINS E 2 , F 2α , PROSTACYCLIN, FLURBIPROFEN AND ASPIRIN ON ARRHYTHMIAS RESULTING FROM CORONARY ARTERY LIGATION IN ANAESTHETIZED RATS
Author(s) -
COKER SUSAN J.,
PARRATT J.R.
Publication year - 1981
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1981.tb09968.x
Subject(s) - prostacyclin , ventricular fibrillation , aspirin , medicine , cardiology , myocardial infarction , ventricular tachycardia , flurbiprofen , ligation , tachycardia , artery , thromboxane , fibrillation , anesthesia , atrial fibrillation , platelet
1 Various prostaglandins and inhibitors of prostaglandin synthesis were administered prior to acute coronary artery ligation in anaesthetized rats and their effects were assessed on the number and severity of the resulting early arrhythmias (ventricular ectopic activity; incidence and duration of ventricular tachycardia and of ventricular fibrillation) 2 Prostaglandin E 2 (PGE 2 ), PGF 2α and prostacyclin all showed antiarrhythmic activity; in contrast flurbiprofen increased the incidence of ventricular fibrillation and mortality 3 Both the number of ventricular ectopic beats and the incidence of ventricular fibrillation were reduced by aspirin 4 The results suggest that the release of endogenous PGE 2 , PGF 2α and prostacyclin could reduce early post‐infarction ventricular arrhythmias whilst the protective effect of aspirin in this model adds further support for the hypothesis that thromboxane release is involved in the genesis of these arrhythmias.