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INHIBITION OF LYMPHOCYTE PROLIFERATION BY HISTAMINE AND RELATED COMPOUNDS NOT MEDIATED VIA H 1‐ OR H 2‐ RECEPTORS
Author(s) -
GORDON D.,
LEWIS G.P.,
NOURI A.M.E.
Publication year - 1981
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1981.tb09965.x
Subject(s) - histamine , receptor , histamine receptor , lymphocyte , chemistry , histamine h4 receptor , histamine h2 receptor , microbiology and biotechnology , immunology , biology , pharmacology , biochemistry , antagonist
1 The effects of histamine and chemical analogues were examined on mitogen‐stimulated human lymphocyte proliferation 2 Compounds with selective agonist activity at either H 1‐ or H 2‐ receptors were found to inhibit proliferative responses, although N‐3‐methyl‐histamine which does not act on either receptor was as inhibitory as histamine itself 3 The H 2‐ receptor agonist, dimaprit, had a profound inhibitory effect on proliferation, however nordimaprit, which has little or no H 2‐ agonist activity, was more active on lymphocytes. Impromidine, although a potent H 2‐ agonist, failed to produce such inhibition 4 The effects of dimaprit and nordimaprit were not reversed by H 2‐ receptor antagonists, cimetidine or metiamide 5 These results do not support the view that the antiproliferative effects of histamine and related compounds are mediated via conventional H 1‐ or H 2‐ receptors 6 SKF 93390 was found to be the most active of the dimaprit analogues tested, which could represent a novel series of potential immunosuppressive agents.