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DIFFERENT MECHANISMS OF ACTION OF HISTAMINE IN ISOLATED ARTERIES OF THE DOG
Author(s) -
KONISHI MAKOTO,
TODA NOBORU,
YAMAMOTO MASAKATSU
Publication year - 1981
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1981.tb09961.x
Subject(s) - cimetidine , histamine , histamine h2 receptor , histamine h1 receptor , mesenteric arteries , medicine , coronary arteries , endocrinology , contraction (grammar) , histamine receptor , anesthesia , chemistry , pharmacology , receptor , artery , antagonist
1 In helically‐cut strips of dog coronary, superior mesenteric, right gastro‐epiploic and renal arteries contracted with prostaglandin F 2β (PGF 2β ), histamine produced a dose‐related relaxation, while, in contrast, the amine caused only a contraction of cerebral arterial strips 2 The contractile response of cerebral arteries to histamine was attenuated by chlorpheniramine (10 −6 M)but was unaffected by cimetidine (10 −5 m). Relaxant responses to histamine of coronary and renal arteries were significantly attenuated by treatment with cimetidine and to a similar extent by combined treatment with cimetidine and chlorpheniramine. Chlorpheniramine alone was ineffective 3 In mesenteric and gastro‐epiploic arteries, relaxant responses to histamine were attenuated only slightly by cimetidine. Chlorpheniramine slowed the development of histamine‐induced relaxations but did not alter the magnitude of the relaxations. Combined treatment with these H 1‐ and H 2‐ antagonists attenuated the histamine‐induced relaxations to an appreciably greater extent than treatment with cimetidine alone 4 It may be concluded that the cerebroarterial contraction induced by histamine is mediated through H 1‐ receptors and the relaxations of coronary and renal arteries induced by histamine are mediated through H 2‐ receptors. It appears that H 1‐ and H 2‐ receptors interact with each other to produce potentiation of histamine‐induced relaxations of mesenteric and gastro‐epiploic arteries.