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POTENTIATION BY NALOXONE OF PRESSOR REFLEXES
Author(s) -
MONTASTRUC JEANLOUIS,
MONTASTRUC PAUL,
MORALESOLIVAS FRANCISCO
Publication year - 1981
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1981.tb09960.x
Subject(s) - (+) naloxone , reflex , stimulation , medicine , morphine , opiate , antagonist , anesthesia , narcotic antagonist , vagus nerve , endocrinology , receptor
1 The effect of intravenous naloxone, an opiate antagonist, was studied on the pressor responses elicited by stimulation of afferent nerves (vagus and laryngeal superior nerves) in anaesthetized dogs 2 Although naloxone (0.1 mg/kgi.v.) alone failed to modify basic blood pressure, the pressor responses induced by stimulation of either the vagus or laryngeal nerve were potentiated by naloxone 3 Morphine (0.2mg/kgi.v.) suppressed these two cardiovascular responses. These depressor effects of morphine were reversed by subsequent injection of naloxone (0.1 mg/kg i.v.) 4 The results suggest the involvement of endogenous opiate peptides in pressor reflexes elicited by stimulation of the afferent nerves.