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USE OF POTENTIATION OF THYROTROPHIN RELEASING HORMONE (TRH)‐INDUCED HYPERTHERMIA AS A TEST FOR SCREENING ANTIDEPRESSANTS WHICH ACTIVATE α‐ADRENOCEPTOR SYSTEMS
Author(s) -
DESILES MARGUERITE,
RIPS RICHARD
Publication year - 1981
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1981.tb09957.x
Subject(s) - maprotiline , clomipramine , tricyclic , endocrinology , long term potentiation , medicine , reserpine , imipramine , pharmacology , nomifensine , amitriptyline , phenoxybenzamine , hyperthermia , chemistry , trazodone , antidepressant , propranolol , receptor , dopamine , alternative medicine , dopaminergic , pathology , hippocampus
1 The minimal dose which significantly potentiates the hyperthermia induced by thyrotrophin releasing hormone (TRH, 40mg/kgi.p.) in mice has been established for tricyclic and other antidepressants (imipramine, amitriptyline, clomipramine, nortriptyline, maprotiline, nomifensine, viloxazine) including a specific inhibitor of noradrenaline (NA) uptake (nisoxetine) 2 The minimal effective dose in this test has been compared with the minimal dose of the same compounds antagonizing reserpine‐induced hypothermia. The ratio of the two doses for each substance indicates that potentiation of TRH‐induced hyperthermia is, in general, the more sensitive test 3 A correlation seems to exist between the α‐adrenergic effect of antidepressants and the potentiation of TRH‐induced hyperthermia. Those antidepressants which do not act on α‐adrenergic systems (butriptyline, amineptine, trazodone, danitracen, fluoxetine) are inactive in this test 4 This property may be used to select antidepressants that activate α‐adrenoceptor systems.