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HISTAMINE RELEASE FROM HUMAN RIGHT ATRIUM
Author(s) -
GRISTWOOD R.W.,
LINCOLN J.C.R.,
OWEN D.A.A.,
SMITH I.R.
Publication year - 1981
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1981.tb09947.x
Subject(s) - histamine , degranulation , cimetidine , inotrope , contraction (grammar) , right atrium , compound 48/80 , atrium (architecture) , medicine , chemistry , pharmacology , endocrinology , receptor , atrial fibrillation
Histamine release has been detected biologically after exposure of human right atrial biopsy samples to compound 48/80. Human right atrial samples contain large quantities of histamine, 1035±65ng/g fresh weight. Exposure of untreated electrically paced atrial strips to compound 48/80, 300 μg/ml, caused an increase in the force of atrial contraction similar to that caused by histamine. Pretreatment of strips with cimetidine, 3.16×10 −5 m, prevented the inotropic response to compound 48/80. It is concluded that mast cell degranulation in human atrial tissue can cause sufficient release of histamine to modify the function of the heart.