Premium
INHIBITION BY CLINICALLY USED DYES OF PROSTAGLANDIN INACTIVATION IN RAT AND HUMAN LUNG
Author(s) -
BAKHLE Y.S.
Publication year - 1981
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1981.tb09153.x
Subject(s) - indocyanine green , methylene blue , chemistry , bioassay , prostaglandin , prostaglandin e2 , lung , bolus (digestion) , pharmacology , medicine , biochemistry , biology , pathology , photocatalysis , genetics , catalysis
1 The effect of several clinically used dyes on prostaglandin E 2 (PGE 2 ) inactivation was studied in rat and human isolated lung. 2 All the dyes, given as infusions through the pulmonary circulation, inhibited the inactivation of PGE 2 as measured by bioassay. The action of the dyes was readily reversible on stopping the infusion. 3 The concentration producing 30% inhibition varied from 0.6 μ m for indocyanine green to over 100 μ m for methylene blue. 4 Inhibition of PGE 2 inactivation was also observed when the dyes were given as bolus injections during PGE 2 infusions through the lung. 5 These dyes are therefore not physiologically inert as they had previously been thought to be and their interaction with prostaglandins may affect the variables they are used to measure.