Premium
ASPIRIN INHIBITS THE EARLY MYOCARDIAL RELEASE OF THROMBOXANE B 2 AND VENTRICULAR ECTOPIC ACTIVITY FOLLOWING ACUTE CORONARY ARTERY OCCLUSION IN DOGS
Author(s) -
COKER SUSAN J.,
LEDINGHAM I. McA.,
PARRATT J.R.,
ZEITLIN I.J.
Publication year - 1981
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1981.tb09138.x
Subject(s) - medicine , cardiology , ventricular fibrillation , aspirin , myocardial infarction , thromboxane , occlusion , artery , anesthesia , coronary sinus , platelet
Acute coronary artery occlusion in anaesthetized open‐chest greyhounds led to early release of thromboxane B 2 (TxB 2 ) into venous blood draining the ischaemic region. No release occurred from the remainder of the left ventricular wall (coronary sinus sampling). TxB 2 release and ventricular ectopic activity were positively correlated ( r = 0.863) 2 min post‐occlusion. Aspirin (3 mg/kg i.v.) suppressed both local TxB 2 release and ectopic activity and prevented ventricular fibrillation. It is suggested that TxB 2 release is a factor contributing to early post‐infarction arrhythmias.