Premium
THE GASTRIC ANTISECRETORY ACTIONS OF PROSTAGLANDIN E 2 AND STABLE PROSTACYCLIN ANALOGUES AGAINST DIFFERENT SECRETAGOGUES IN PERFUSED WHOLE‐STOMACHS OF RAT OR MOUSE in vitro
Author(s) -
BOUGHTONSMITH N.K.,
WHITTLE B.J.R.
Publication year - 1981
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1981.tb09128.x
Subject(s) - histamine , medicine , prostacyclin , pentagastrin , endocrinology , stomach , stimulation , gastric acid , prostaglandin , methacholine , prostaglandin e2 , adenosine , biology , secretion , prostaglandin e , chemistry , respiratory disease , lung
1 The characteristics of the antisecretory actions of prostaglandin E 2 (PGE 2 ) and two stable prostacyclin analogues during different rates of acid stimulation have been evaluated in the lumen‐perfused isolated whole stomach of the rat and mouse. 2 In the rat isolated stomach, histamine induced a dose‐dependent increase in acid output. Preincubation with PGE 2 caused a dose‐related and surmountable inhibition. 3 The stable prostacyclin analogues, 6β‐PGI 1 and a 16‐phenoxy derivative likewise caused a surmountable inhibition of histamine‐stimulated acid output from rat stomach. 4 PGE 2 had inconsistent actions on the acid secretion stimulated by pentagastrin, methacholine or dibutyryl cyclic adenosine 3′,5′‐monophosphate. 5 In the mouse isolated stomach, acid secretion was stimulated by low concentrations of histamine, pentagastrin or methacholine. 6 PGE 2 failed to inhibit histamine‐stimulated acid output from mouse stomach, but high concentrations of the potent 16‐phenoxy analogue did show anti‐secretory activity. 7 The results indicate the usefulness of the rat isolated stomach for studying the interaction of prostaglandins with the acid secretory process in mammalian gastric mucosa.