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EFFECTS OF NERVE STIMULATION AND OF ADMINISTRATION OF NORADRENALINE OR POTASSIUM CHLORIDE UPON THE RELEASE OF PROSTAGLANDINS I 2 , E 2 AND F 2α FROM THE PERFUSED MESENTERIC ARTERIAL BED OF THE RABBIT
Author(s) -
PIPILI EVA,
POYSER N.L.
Publication year - 1981
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1981.tb09109.x
Subject(s) - potassium , stimulation , chemistry , nerve stimulation , chloride , norepinephrine , medicine , endocrinology , dopamine , organic chemistry
1 The release of prostaglandin I 2 (PGI 2 ), PGE 2 and PGF 2α from the perfused mesenteric arterial bed of the rabbit was examined at rest, following nerve stimulation and following noradrenaline (NA) or potassium chloride (KCl) administration. 2 Stimulation of adrenergic nerves at 10 Hz caused a significant increase in the release of both PGI 2 , (assayed in terms of 6‐oxo‐PGF 1α ) and PGE 2 but a significant decrease in the release of PGF 2α . 3 Exogenous Na (2 μg) increased the output of PGI 2 and PGE 2 but left the output of PGF 2α unaffected. 4 KCl (15 mg) significantly increased the output of PGF 2α but left the output of PGI 2 unaffected. 5 It is concluded that PGI 2 and PGE 2 output from the mesenteric arterial bed of the rabbit increases following stimulation of adrenoceptors. The sympathetic nervous system may therefore modulate PGI 2 /platelet interaction. 6 Prostaglandins released from the blood vessels by sympathetic nerve stimulation may also modulate adrenergic transmission to the blood vessels.