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INHIBITION OF LYMPHOCYTE CAPPING AND TRANSFORMATION BY PROPRANOLOL AND RELATED COMPOUNDS
Author(s) -
ANDERTON BRIAN H.,
AXFORD JOHN S.,
COHN PETER,
MARSHALL NICHOLAS J.,
SHEN LI,
SPRAKE SALLY
Publication year - 1981
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1981.tb09106.x
Subject(s) - propranolol , alprenolol , quinidine , practolol , phytohaemagglutinin , chemistry , pharmacology , transformation (genetics) , lymphocyte , biochemistry , endocrinology , biology , immunology , in vitro , gene
1 The effects of propranolol on phytohaemagglutinin (PHA)‐induced transformation of murine T lymphocytes and capping of anti‐IgG on the surface of murine B lymphocytes have been examined. 2 A 50% inhibition of transformation was observed with 10 −5 m propranolol, whereas a higher concentration, of the order of 10 −3 m propranolol was required to inhibit capping by 50%. The (+)‐and (−)‐isomers of propranolol proved equipotent in these respects, and the relative potencies of selected analogues of propranolol (alprenolol, oxprenolol, metoprolol, practolol and sotalol) coincided with their potencies as membrane stabilizers; however, lymphocyte transformation was consistently more sensitive than capping. 3 Similar effects were also seen with quinidine, chlorpromazine and lignocaine, and it was concluded that the inhibition of both lymphocyte functions was due to the membrane stabilizing actions of propranolol.