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GENDER DIFFERENCES IN PROSTAGLANDIN RECEPTORS OF RAT AORTA
Author(s) -
KARANIAN J.W.,
MORAN F.M.,
RAMEY E.R.,
RAMWELL P.W.
Publication year - 1981
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1981.tb09097.x
Subject(s) - endocrinology , medicine , aorta , receptor , prostaglandin , thoracic aorta , testosterone (patch) , alpha (finance) , biology , chemistry , construct validity , patient satisfaction , nursing
The maximal contractile response to the prostaglandin endoperoxide H 2 analogue U46619, prostaglandins E 2 , D 2 and F 2α and the sensitivity of the superfused aorta preparation to these drugs (except PGF 2α ) is greater in the male than the female rat. In contrast, gender differences were not observed in the response to noradrenaline or 5‐hydroxytryptamine. In previous studies, testosterone unlike oestrogen or progesterone, increased the response of both rabbit and rat aorta to U46619. We conclude that prostaglandin receptors in rat thoracic aorta may be hormonally regulated.