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EFFECT OF FATTY ACIDS ON THE VENTRICULAR ARRHYTHMIA THRESHOLD IN THE ISOLATED HEART OF THE RABBIT
Author(s) -
MURNAGHAN MAURICE F.
Publication year - 1981
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1981.tb08745.x
Subject(s) - polyunsaturated fatty acid , ventricle , chemistry , hypoxia (environmental) , lauric acid , medicine , fatty acid , saturated fatty acid , endocrinology , biochemistry , oxygen , organic chemistry
1 The ventricular arrhythmia threshold (VAT) was measured in the isolated Ringer‐perfused rabbit heart (Langendorff preparation) by applying a single 10 ms square‐wave pulse of current to the left ventricle during the vulnerable period of late systole under normoxic and hypoxic conditions. 2 The sodium salt of the fatty acid was bound to albumen and incorporated in the Krebs‐Henseleit solution which was maintained at 37°C and gassed with 95% O 2 and 5% CO 2 (normoxia) or 5% CO 2 in air (hypoxia). 3 Saturated fatty acids failed to alter the VAT under normoxia. 4 Naturally occurring long‐chained saturated and mono‐unsaturated fatty acids with chain lengths varying from 14 to 20 carbons, but not the 12 carbon lauric acid, potentiated the effect of the hypoxia in lowering the VAT. 5 Short‐chained 8 and 10 carbon saturated and long‐chained polyunsaturated fatty acids antagonized the effect of hypoxia on the VAT. 6 In addition the polyunsaturated acids antagonized the potentiating effect of the long‐chained saturated and mono‐unsaturated acids on the hypoxia in lowering the VAT. 7 The fatty acids did not alter the duration or type of the induced arrhythmia.