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EFFECT OF GENDER ON DEVELOPMENT AND DIURNAL RHYTHM OF PROSTAGLANDIN RECEPTORS IN RAT AORTA
Author(s) -
KARANIAN J.W.,
RAMEY E.R.,
RAMWELL P.W.
Publication year - 1981
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1981.tb08744.x
Subject(s) - endocrinology , medicine , aorta , testosterone (patch) , prostaglandin , prostaglandin analogue , androgen , receptor , rhythm , chemistry , biology , hormone
1 The prostaglandin endoperoxide H 2 analogue, U‐46619 (15‐hydroxyll, 9‐epoxymethano‐prosta‐5Z, 13E‐enoic acid), was used to determine the effect of gender on the isotonic contractile response of the superfused rat aorta preparation over a 24 h period and at 10 and 16 weeks of age. 2 The maximal responses of the male aortae were 20 ± 3% and 36 ± 4% (P< 0.001) greater than the female at 10 and 16 weeks, respectively. Similarly, sensitivity of the male aorta to the PGH 2 analogue increased with age. 3 The male but not the female exhibited a diurnal rhythm in which both the maximum contractile response and sensitivity were significantly decreased at night. 4 We conclude that these gender differences may be related to the secretion of androgen, since reported peak serum testosterone over a 24 h period and testosterone changes with maturation are coincident with the maximum response of male aortae to the PGH 2 analogue.