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MORPHINE‐THEOPHYLLINE INTERACTION: ANTAGONISM OR FACILITATION?
Author(s) -
BRAILOWSKY SIMÓN,
GUERREROMUN̆OZ FEDERICO,
LUJÁN MIGUEL,
SHKUROVICH MARIO
Publication year - 1981
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1981.tb08742.x
Subject(s) - antagonism , theophylline , facilitation , morphine , pharmacology , medicine , neuroscience , anesthesia , psychology , receptor
1 Morphine‐theophylline interactions were investigated in both acute and narcotic‐dependent preparations, in vitro and in vivo , using four different experimental models: LD 50 doses of morphine and naloxone in the mouse; naloxone‐induced contractions in the electrically‐stimulated and opiate‐dependent isolated ileum of the guinea‐pig; naloxone‐induced jumps in the mouse; and calcium uptake in synaptosomal preparations. 2 The LD 50 of morphine was significantly increased by theophylline. 3 The lethal effect of theophylline was potentiated by pretreatment of the animals with naloxone. 4 Theophylline displayed protective effects in the inhibitory response to morphine and antagonism to the withdrawal response induced by naloxone in the electrically‐stimulated isolated ileum of the guinea‐pig. 5 The number of jumps induced by naloxone in morphine‐dependent mice was significantly diminished by theophylline. 6 The inhibitory effect of morphine on the synaptosomal uptake of calcium was decreased by theophylline. 7 The effects of both morphine and theophylline on the cyclic nucleotides and the possible role of calcium in these actions are discussed.