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ANTAGONISM OF OPIATE MYDRIASIS IN MICE
Author(s) -
KORCZYN AMOS D.,
ROCK MEIR
Publication year - 1981
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1981.tb08732.x
Subject(s) - mydriasis , antagonism , opiate , medicine , pharmacology , neuroscience , anesthesia , biology , receptor
1 Morphine‐induced mydriasis in mice is antagonized by nalorphine, levallorphan and naloxone in a dose‐dependent manner. 2 The relative potency of the three agents is 10: 56: 134 respectively, thus being in accordance with other tests of narcotic antagonism. Naloxone has the shortest duration of action. 3 When injected into naive animals, nalorphine (but not levallorphan or naloxone) produces a slight mydriasis. 4 Measurement of the diameter of the pupil in mice seems to be a precise, simple and rapid test for studying narcotic antagonist as well as agonist action and has several advantages over standard methods used for this purpose.