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THE BINDING OF SOME ANTIDEPRESSANT DRUGS TO BRAIN MUSCARINIC ACETYLCHOLINE RECEPTORS
Author(s) -
GOLDS P.R.,
PRZYSLO F.R.,
STRANGE P.G.
Publication year - 1980
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1980.tb14570.x
Subject(s) - maprotiline , muscarinic acetylcholine receptor , pharmacology , muscarinic acetylcholine receptor m4 , muscarinic acetylcholine receptor m5 , mianserin , muscarinic acetylcholine receptor m3 , acetylcholine , atropine , chemistry , nomifensine , muscarinic acetylcholine receptor m2 , anticholinergic , muscarinic acetylcholine receptor m1 , antidepressant , medicine , receptor , endocrinology , biochemistry , dopaminergic , hippocampus , dopamine
1 The binding of some antidepressant drugs, including some new drugs of atypical structure (flupenthixol, iprindole, maprotiline, mianserin, nomifensine, tofenacine and viloxazine) to muscarinic acetylcholine receptors in the brain has been studied by displacement of [ 3 H]‐atropine. 2 Many of the drugs are potent muscarinic antagonists. 3 Some correlation can be made between the affinity for binding to the muscarinic acetylcholine receptor and the incidence of anticholinergic side effects in clinical usage.