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BLOCKADE OF ADRENALINE‐INDUCED HYPERGLYCAEMIA IN THE ANAESTHETIZED CAT BY CONTINUOUS INFUSION OF PHENTOLAMINE AND PROPRANOLOL
Author(s) -
ALJIBOURI LAYLA M.,
FURMAN B.L.,
PARRATT J.R.
Publication year - 1980
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1980.tb14559.x
Subject(s) - phentolamine , propranolol , medicine , blockade , anesthesia , epinephrine , sympatholytics , adrenergic beta antagonists , endocrinology , receptor
1 The effects of adrenoceptor blocking drugs on the metabolic responses to adrenaline infusion (1 μg kg −1 min −1 ) have been studied in the anaesthetized, fasted cat. 2 Propranolol, in doses (0.25 or 1 mg/kg) which prevented completely adrenaline‐induced tachycardia, reduced but did not abolish adrenaline‐induced hyperglycaemia. 3 Phentolamine infusion, at a rate (15 μg kg −1 min −1 after a priming dose of 2.5 mg/kg) which reversed the pressor effect of adrenaline, reduced but did not abolish adrenaline‐induced hyperglycaemia. 4 The continuous infusion of a combination of phentolamine (15 μg kg −1 min −1 after a priming dose of 2.5 mg/kg) and propranolol (5 μg kg −1 min −1 after a priming dose of 0.25 mg/kg) prevented completely the hyperglycaemia response to adrenaline infusion over a 6 h period. 5 The increase in blood lactate concentration produced by adrenaline was prevented completely by the combined infusion of propranolol and phentolamine but was not modified by phentolamine alone.