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INVESTIGATION OF THE ANTIFIBRILLATORY ACTIVITY OF SOME ANTICONVULSANT γ‐AMINOBUTYRIC ACID‐TRANSAMINASE INHIBITORS IN THE RABBIT ISOLATED HEART: COMPARISON WITH PHENYTOIN AND MEXILETINE
Author(s) -
ALMOTREFI A.A.,
BAKER J.B.E.
Publication year - 1980
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1980.tb10984.x
Subject(s) - mexiletine , phenytoin , anticonvulsant , pharmacology , chemistry , perfusion , gaba transaminase , valproic acid , stimulation , transaminase , levetiracetam , medicine , anesthesia , endocrinology , epilepsy , enzyme , biochemistry , glutamate decarboxylase , psychiatry
1 The electrical stimulation and ventricular fibrillation thresholds were measured in the Langendorff‐perfused rabbit heart by application of rectangular impulses of 3 ms duration and increasing current at frequencies of 4 and 20 Hz respectively. 2 Perfusion with either phenytoin or mexiletine produced significant dose‐dependent increases in both thresholds. 3 Perfusion with four anticonvulsant inhibitors of γ‐aminobutyric acid (GABA)‐transaminase, amino‐oxyacetic acid, γ‐acetylenic GABA, γ‐vinyl GABA and sodium valproate, up to a concentration of 20 μg/ml, had no significant effect on either threshold. 4 The results suggest that these compounds, unlike phenytoin and mexiletine, are devoid of antifibrillatory activity.