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PROPHYLACTIC LIGNOCAINE AND EARLY POST‐CORONARY ARTERY OCCLUSION DYSRHYTHMIAS IN ANAESTHETIZED GREYHOUNDS
Author(s) -
MARSHALL R.J.,
PARRATT J.R.
Publication year - 1980
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1980.tb10978.x
Subject(s) - medicine , myocardial infarction , ventricular fibrillation , cardiology , coronary artery occlusion , anesthesia , artery , lidocaine , ligation , occlusion , coronary occlusion
1 Lignocaine (1 mg kg −1 min −1 infused intravenously for 30 min) greatly reduced the incidence of ventricular ectopic beats that resulted from acute coronary artery ligation in anaesthetized greyhound dogs. However, the incidence of ventricular fibrillation was only slightly reduced by this treatment which caused significant myocardial depression. 2 There is no good evidence from this study that lignocaine is a particularly effective prophylactic in acute myocardial infarction.