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A STUDY OF γ‐AMINOBUTYRIC ACID UPTAKE IN NORMAL AND DOWN'S SYNDROME PLATELETS
Author(s) -
ENNS LOUISE,
McCOY E.E.
Publication year - 1980
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1980.tb10972.x
Subject(s) - platelet , chemistry , medicine , endocrinology , biochemistry , biology
1 Initial uptake rates of γ‐aminobutyric acid (GABA) were compared in Down's syndrome (D.S.) and normal platelets. GABA uptake was decreased in D.S. platelets (1.10 ± 0.10 nmol h −1 10 −9 ) compared to uptake by normal platelets (1.89 ± 0.21 nmol h −1 10 −9 ), P < 0.005. 2 The effect of varying the Na + concentration was similar on D.S. and normal platelets. Increasing the media Na + concentration resulted in increased rates of GABA uptake in both D.S. and normal platelets. 3 GABA uptake in the presence of 2,4‐dinitrophenol or at 2°C is approximately 56% of the uptake at 37°C for both D.S. and normal platelets. 4 Extrapolation of a reciprocal plot indicates a two affinity uptake system: a high affinity and a low affinity mechanism. 5 A significant defect in GABA uptake exists in D.S. platelets.