Premium
ANTAGONIST DISCRIMINATION BETWEEN GANGLIONIC AND ILEAL MUSCARINIC RECEPTORS
Author(s) -
BROWN D.A.,
FORWARD A.,
MARSH S.
Publication year - 1980
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1980.tb10948.x
Subject(s) - pirenzepine , muscarinic acetylcholine receptor , ileum , antagonist , endocrinology , medicine , atropine , muscarinic acetylcholine receptor m3 , receptor , muscarinic acetylcholine receptor m2 , methiodide , affinities , depolarization , contraction (grammar) , chemistry , biology , anatomy , biochemistry
The effects of four antagonists on the depolarization of isolated superior cervical ganglia and the contraction of isolated ileal segments of the rat were compared. pA 2 values estimated from Schild plots indicated significantly higher affinities of stercuronium (x 100) and pirenzepine (x 23) and a significantly lower affinity of 4‐diphenylacetoxy‐ N ‐methylpiperidine methiodide (x 0.39) for the ganglion than for the ileum. The affinities of N ‐methylscopolamine for the two tissues were not significantly different. It is concluded that the two types of muscarinic receptor are not identical.