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ANTI‐TREMOR ACTION OF C 10 DICHOL, A PERIPHERAL ACETYLCHOLINE SYNTHESIS INHIBITOR
Author(s) -
DAS M.,
GANGULY D.K.,
VEDASIROMONI J.R.
Publication year - 1980
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1980.tb10946.x
Subject(s) - physostigmine , oxotremorine , acetylcholine , pharmacology , medicine , nicotine , neuromuscular junction , arecoline , chemistry , muscarinic acetylcholine receptor , neuroscience , biology , receptor
1 Anti‐tremor action of decamethylene bis‐(hydroxyethly)‐dimethylammonium bromide (C 10 Dichol), a peripheral acetylcholine synthesis inhibitor, was investigated. 2 C 10 Dichol inhibited tremor induced by oxotremorine, nicotine and physostigmine and afforded partial protection from physostigmine‐induced mortality in mice. 3 In non‐paralysing doses, C 10 Dichol antagonized the neuromuscular effects of oxotremorine, nicotine and physostigmine. 4 Prior administration of C 10 Dichol failed to prevent tremor and neuromuscular paralysis induced by harmine and arecoline. 5 In the absence of any antimuscarinic property of C 10 Dichol, its neuromuscular effects appeared to be causually related to its anti‐tremor action. 6 This study reveals a possibility for the development of peripherally acting anti‐Parkinson drugs.