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EFFECTS OF SOME S ‐ALKYLTHIOURONIUMS AND RELATED COMPOUNDS ON THE OSMOTIC FRAGILITY AND THE MEMBRANE EXPANSION OF HUMAN ERYTHROCYTES
Author(s) -
BERESFORD ROSEMARY A.,
FASTIER F.N.
Publication year - 1980
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1980.tb10933.x
Subject(s) - erythrocyte fragility , chemistry , membrane , erythrocyte membrane , biophysics , biochemistry , biology , medicine , hemolysis
1 Changes in the osmotic fragility and critical haemolytic volume of human erythrocytes produced by S‐n ‐decylthiouronium (S‐10) and related compounds have been studied. 2 S‐10 had a biphasic action on osmotic fragility, protecting erythrocytes against lysis in low concentrations but producing lysis in a concentration of 1 m m or higher. 3 Some lower homologues of S‐10 also protected erythrocytes against osmotic lysis, the degree of protection depending on the length of the alkyl chain. 4 Critical haemolytic volume was increased by anthihaemolytic concentrations of procaine and chlorpromazine but not by antihaemolytic concentrations of S‐10 and related amidines. 5 It is concluded that S‐10 and its near homologues penetrate and stabilize erythrocyte membranes, potency increasing with the number of methylene groups in the side‐chain up to about ten. The stabilization produced by S‐10 apparently differs from that produced by many other lipid‐soluble depressant drugs. It may be related to a drug‐induced change in the ionic permeability of the membrane.