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A COMPARISON OF THE EFFECTS OF PANCURONIUM BROMIDE AND ITS MONOQUATERNARY ANALOGUE, ORG NC 45, ON AUTONOMIC AND SOMATIC NEUROTRANSMISSION IN THE RAT
Author(s) -
DOCHERTY J.R.,
McGRATH J.C.
Publication year - 1980
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1980.tb10930.x
Subject(s) - pancuronium bromide , chemistry , neurotransmission , pharmacology , anesthesia , neuroscience , medicine , receptor , psychology , biochemistry
1 Potentiation by pancuronium of the effects of adrenergic nerve stimulation, previously shown in cardiovascular tissues, was also found in rat anococcygeus and vas deferens, in vitro or in vivo.2 In the pithed rat, in the presence of pancuronium, pre‐junctional α‐adrenoceptor‐mediated feedback inhibition of cardiac sympathetic transmission was uncovered at relatively low stimulation frequencies by phentolamine or yohimbine. 3 The effects of pancuronium and its mono‐quaternary analogue Org NC 45 on autonomic and somatic neuromuscular transmission were compared, in the pithed rat. Org NC 45 was less potent than pancuronium at blocking somatic neuromuscular transmission by a factor of 2.1, at blocking cardiac, parasympathetic transmission by a factor of 538 and at potentiating sympathetic transmission by a factor of 33.