Premium
INVESTIGATION OF ACTION OF ENKEPHALIN ON THE SPONTANEOUS AND EVOKED RELEASE OF ACETYLCHOLINE FROM RAT CORTICAL AND STRIATAL SLICES
Author(s) -
JHAMANDAS K.,
ELLIOTT J.
Publication year - 1980
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1980.tb10928.x
Subject(s) - veratridine , acetylcholine , enkephalin , chemistry , striatum , ouabain , endocrinology , medicine , cortex (anatomy) , met enkephalin , neuroscience , sodium , biology , dopamine , biochemistry , receptor , opioid , sodium channel , organic chemistry
1 The effects of two synthetic enkephalins, d ‐Ala 2 ‐Met 5 ‐enkephalinamide (DALA) and d ‐Ala 2 ‐MePne 4 ‐Met 5 ‐(0)‐ol‐enkephalin (33,824) were tested on the spontaneous and stimulated release of acetylcholine (ACh) from rat cortical and striatal slices. 2 DALA, but not 33,824, caused a modest increase in spontaneous cortical ACh release. Neither enkephalin affected the release of cortical ACh induced by high potassium (25 m m ) or veratridine (20 μ m ). 3 DALA had no effect on the release of ACh from striatal slices occurring spontaneously or in the presence of potassium (25 m m ), veratridine (5 μ m ) or ouabain (10 μ m ). The enkephalin 33,824 also had no significant action on the striatal ACh release except that it caused a slight enhancement of veratridine‐evoked release. 4 It is suggested that enkephalins have no significant action on release of ACh from the cortex or striatum in vitro. Their action on ACh release from the cortex in vivo , seen in previous studies, may be exerted at a subcortical level.