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THE ACTION OF SODIUM CROMOGLYCATE ON ‘C’ FIBRE ENDINGS IN THE DOG LUNG
Author(s) -
DIXON M.,
JACKSON D.M.,
RICHARDS I.M.
Publication year - 1980
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1980.tb10898.x
Subject(s) - sodium cromoglycate , free nerve ending , capsaicin , microgram , chemistry , lung , disodium cromoglycate , medicine , endocrinology , anesthesia , asthma , biochemistry , receptor , in vitro
The effect has been studied of sodium cromoglycate (SCG) on the activity of ‘C’ fibre sensory nerve endings in the canine lung. Pretreatment with SCG (100 μg/kg i.v.) reduced the excitation of these endings by capsaicin (10 μg/kg i.v.) for approximately 45 min. This property of SCG may explain its ability to suppress certain types of bronchoconstrictor responses in man.