Premium
OXOTREMORINE DOES NOT ENHANCE ACETYLCHOLINE RELEASE FROM RAT DIAPHRAGM PREPARATIONS
Author(s) -
GUNDERSEN CAMERON B.,
JENDEN DONALD J.
Publication year - 1980
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1980.tb10897.x
Subject(s) - oxotremorine , acetylcholine , choline , chemistry , diaphragm (acoustics) , muscarinic acetylcholine receptor , endocrinology , chromatography , medicine , biochemistry , biology , physics , receptor , acoustics , loudspeaker
We have reinvestigated the dramatic effect of oxotremorine on acetylcholine release from the rat diaphragm reported by Das, Ganguly & Vedasiromoni (1978), using a rigorous gas chromatographic mass spectrometric/isotope dilution method for identification and measurement of acetylcholine and choline. Oxotremorine (10 μm) causes no significant change in the spontaneous or evoked (1 or 10 Hz) release or in the tissue levels of acetylcholine or choline.