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DESENSITIZATION OF THE ACETYLCHOLINE RECEPTOR OF DENERVATED RAT SOLEUS MUSCLE AND THE EFFECT OF CALCIUM
Author(s) -
ANWYL ROGER,
NARAHASHI TOSHIO
Publication year - 1980
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1980.tb10886.x
Subject(s) - acetylcholine , desensitization (medicine) , chemistry , calcium , endocrinology , medicine , muscarinic acetylcholine receptor , acetylcholine receptor , receptor , biology , biochemistry
1 Desensitization of the extrajunctional acetylcholine receptors of denervated rat soleus muscle has been studied by evoking iontophoretic acetylcholine potentials at a high frequency (10 Hz). 2 Desensitization occurred with a slow and at least one fast component. 3 Increasing the dose of acetylcholine decreased the half time of onset of desensitization, but did not alter recovery half time. 4 Alteration of external calcium between 0 and 50 m m , or perfusion with agents which increase intracellular calcium such as 2,4‐dinitrophenol and the calcium ionophores, X537A and A23187, did not alter desensitization half time. 5 The cholinoceptor agonists acetylcholine, acetylthiocholine, tetramethylammonium and phenyltrimethylammonium all caused desensitization at the same rate.