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INFLUENCE OF β‐ADRENOCEPTOR BLOCKING AGENTS ON THE TURNOVER RATE OF CARDIAC AND SPLENIC NORADRENALINE IN RATS
Author(s) -
ALEXANDRE J.M.,
CHEVILLARD C.
Publication year - 1980
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1980.tb10880.x
Subject(s) - practolol , pindolol , acebutolol , propranolol , alprenolol , bretylium , chemistry , medicine , endocrinology , heart rate , pharmacology , adrenergic , receptor , blood pressure
1 The effects of (+) and (±)‐propranolol, pindolol, alprenolol, practolol, acebutolol and bretylium were studied on the turnover rate of noradrenaline in heart and spleen of rats. 2 Bretylium (8 mg/kg) greatly reduced the turnover rate of noradrenaline in both organs. 3 (+)‐Propranolol (4 and 10 mg/kg) also diminished the turnover rate of noradrenaline, but its effects were smaller than those of (±)‐propranolol (4 and 10 mg/kg). 4 Pindolol (300 μg/kg) greatly increased the turnover rate of noradrenaline; this effect was especially important in the spleen. 5 Alprenolol (4 and 10 mg/kg) acebutolol (20 and 40 mg/kg) practolol (10 mg/kg) did not produce any significant change. 6 These effects are compatible with the view that β‐adrenoceptor blocking agents may affect noradrenaline release in different manners: anaesthetic properties of some of these drugs and blockade of β 2 prejunctional adrenoceptors produce a diminished release of transmitter, whereas the intrinsic sympathomimetic action of pindolol causes the opposite effect.