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THE EFFECTS OF AROMATIC AMINO ACID DERIVATIVES ON THE EXCITABILITY OF AN IDENTIFIABLE GIANT NEURONE OF THE AFRICAN GIANT SNAIL ( Achatina fulica Férussac)
Author(s) -
TAKEUCHI HIROSHI,
TAMURA HIROKO
Publication year - 1980
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1980.tb10879.x
Subject(s) - achatina , snail , biology , zoology , anatomy , chemistry , ecology
1 The effects of derivatives of aromatic amino acids on the excitability of an identifiable giant neurone (TAN, tonically autoactive neurone) of the African giant snail ( Achatina fulica Férussac) were examined. 2 The following substances had marked inhibitory effects on TAN using bath application: N‐β‐phenylpropionyl‐ l ‐Tyr and N‐β‐phenylpropionyl‐ l ‐Trp (critical concentration, 3 × 10 −7 m ), N‐β‐phenylpropionyl‐ l ‐Phe, N‐cinnamoyl‐ dl ‐Trp and N‐phenoxyacetyl‐ l ‐Trp (critical concentration, 10 −5 to 3 × 10 −5 m ). However, N‐β‐phenylpropionyl‐ d ‐Tyr and N‐β‐phenylpropionyl tyramine had no effect. 3 Microdrop (150 μm in diameter) application of a solution of N‐β‐phenylpropionyl‐ l ‐Tyr or N‐β‐phenylpropionyl‐ l ‐Trp containing about 100 pg resulted in marked inhibitory effects on TAN. The effect was observed in Ca 2+ ‐free, Mg 2+ ‐rich (24 m m ) solution. Substitution of Cl − by acetate did not alter the response. This indicates that the two substances act directly on the TAN membrane and not via synaptic influences, and that the inhibition produced by the two substances is not due to the permeability increase of the TAN membrane to Cl − .

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