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INCREASE IN EPITHELIAL CYCLIC ADENOSINE 3′,5′‐MONOPHOSPHATE FOLLOWING VANADATE
Author(s) -
CUTHBERT A.W.,
HERRERA F.C.,
SCHUZ A.D.,
WILSON S.A.
Publication year - 1980
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1980.tb10875.x
Subject(s) - vanadate , adenosine , cyclase , isoprenaline , endocrinology , medicine , stimulation , cyclic gmp , chemistry , biology , enzyme , biochemistry
Vanadate increases the cyclic adenosine 3′,5′‐monophosphate (cyclic AMP) content of frog skin epithelium and apparently antagonizes the stimulation by isoprenaline. The effect appears to be a direct activation of adenyl cyclase. This new effect of vanadate together with the inhibitory effects on Na‐K ATPase may explain the irregular effects on sodium transport.