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IMPROMIDINE (SK&F 92676) ACTS AS A PARTIAL AGONIST ON THE ISOLATED WHOLE STOMACH OF THE RAT
Author(s) -
PARSONS M.,
SYKES C.
Publication year - 1980
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1980.tb10874.x
Subject(s) - histamine , agonist , partial agonist , medicine , histamine h2 receptor , stomach , endocrinology , chemistry , receptor , biology , antagonist
The present secretory studies on the isolated stomach of the rat provide evidence that impromidine acts as a partial agonist at the histamine H 2 ‐receptors. It was found to be 100 times more potent than histamine but with a maximal response only 50% that obtained with histamine.