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DETERMINATION OF SPECIFIC INHIBITORS OF THROMBOXANE A 2 FORMATION
Author(s) -
LADD N.,
LEWIS G.P.
Publication year - 1980
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1980.tb10873.x
Subject(s) - chemistry , pharmacology , computational biology , medicine , biology
Activation of platelets by contact with collagen leads to the simultaneous formation of a prostaglandin and thromboxane (TXA 2 ), which can be assayed biologically with the superfused rabbit aorta and rat stomach strip. By this method it has been shown that a cyclo‐oxygenase inhibitor, aspirin, inhibited formation of both prostaglandin and TXA 2 while a specific TXA 2 synthetase inhibitor, clotrimazole, inhibited only TXA2 formation. The method is suitable as a primary screen in the search for TXA 2 specific synthetase inhibitors.