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REMOVAL OF INTERNALLY DEPOSITED GOLD BY 2,3‐DIMERCAPTOPROPANE SODIUM SULPHONATE (DIMAVAL)
Author(s) -
GABARD B.
Publication year - 1980
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1980.tb10850.x
Subject(s) - antidote , chemistry , sodium , dimercaprol , excretion , pharmacology , biochemistry , toxicity , medicine , organic chemistry
1 Orally administered 2,3‐dimercaptopropane sodium sulphonate (DMPS, Dimaval) reduced the concentration of gold in rats treated with Auro‐Detoxin and increased the urinary excretion of the metal. 2 In a long‐term experiment, DMPS decreased significantly the concentration of gold in the kidneys and in the skin and increased it in plasma. 3 DMPS appears to be of interest as a possible antidote to gold, which could replace the more toxic 2,3‐dimercaptopropanol (BAL).