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DIFFERENTIAL EFFECTS OF THE CALCIUM‐ANTAGONISTIC VASODILATORS, NIFEDIPINE AND VERAPAMIL, ON THE TRACHEAL MUSCULATURE AND VASCULATURE OF THE DOG
Author(s) -
HIMORI N.,
TAIRA N.
Publication year - 1980
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1980.tb10848.x
Subject(s) - verapamil , nifedipine , vasodilation , isoprenaline , calcium , medicine , papaverine , blood flow , anesthesia , stimulation
In anaesthetized dogs the trachea in situ was perfused arterially with blood, and drugs were injected intra‐arterially. Isoprenaline and the calcium‐antagonistic vasodilators, nifedipine and verapamil, increased tracheal blood flow and decreased resting tone of the trachea. Isoprenaline was equi‐effective in producing tracheal vasodilatation and tracheal dilatation. The two calcium‐antagonistic vasodilators were less effective tracheal dilators than tracheal vasodilators.