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EFFECTS OF 5‐HYDROXYTRYPTOPHOL, A 5‐HYDROXYTRYPTAMINE METABOLITE, ON ISOLATED CEREBRAL ARTERIES OF THE DOG
Author(s) -
FU L.H. WANG,
HAYASHI SHIGEHIRO,
TODA NOBORU
Publication year - 1980
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1980.tb10692.x
Subject(s) - contraction (grammar) , receptor , medicine , prostaglandin , metabolite , prostaglandin d2 , endocrinology , chemistry
5‐Hydroxytryptophol (5‐HTOL) caused a dose‐dependent contraction of helically‐cut strips of dog cerebral arteries. The 5‐HTOL‐induced contraction was suppressed by cinanserin, as was the contraction induced by 5‐hydroxytryptamine (5‐HT). Treatment with 5‐HTOL shifted the dose‐response curve for 5‐HT to the right and downward in a dose‐dependent manner, but did not attenuate the contractile response to prostaglandin F 2α . It may be concluded that 5‐HTOL elicits cerebroarterial contractions by activating tryptaminergic receptors and also interferes with the action of 5‐HT on the receptors.